Antigen delivery by α2 -macroglobulin enhances the cytotoxic T lymphocyte response
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منابع مشابه
Receptor-Mediated Antigen Delivery by α2-Macroglobulin: Effect on Cytotoxic T Lymphocyte Immunity and Implications for Vaccine Development by
Receptor-Mediated Antigen Delivery by α2-Macroglobulin: Effect on Cytotoxic T Lymphocyte Immunity and Implications for Vaccine Development by Edith Villette Bowers Department of Pathology Duke University Date:_______________________ Approved: ___________________________ Salvatore V. Pizzo, MD, PhD, Supervisor ___________________________ George J. Cianciolo, PhD ___________________________ Soman...
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The proteinase "inhibitor" alpha 2-macroglobulin (alpha 2M) is able to entrap and form covalent linkages with diverse proteins during a transient proteinase-activated state. These complexes are rapidly endocytosed after binding to receptors present on macrophages and other cells. We have previously shown that compared to free hen egg lysozyme (HEL), alpha 2M-complexed HEL undergoes enhanced mac...
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ژورنال
عنوان ژورنال: Journal of Leukocyte Biology
سال: 2009
ISSN: 0741-5400
DOI: 10.1189/jlb.1008653